Mr. Vladimir Tomenko
This work is part of the F&F project. The main objective of the work is to assess the impact of endocrine disrupting compounds, which are present in pharmaceutical products, on human fecundity and fertility. The work will aim to quantify the risks, associated with the presence of both known and suspected endocrine disrupting compounds in the environment.

Effects on human fecundity will be assessed with the help of calibrated in vivo tests, and exposure levels for selected compounds will be estimated. The results will be combined in order to characterize risk for populations of concern.

The risk characterization will be performed on the basis of approaches, currently accepted by regulatory agencies (NOAEL/LOAEL, BMD) as well as novel but increasingly exploited ones (non-threshold methods, probabilistic approach). The latter will enable to take into account uncertainties of estimates and escape from the certain conservatism, inherent in adopted approaches.